Temperature impacts Atlantic salmon's (Salmo salar) immunological response to infectious salmon anemia virus (ISAv).

Highlights • 1-Mortality due to ISAv exposure was significantly higher at 10 °C compared to 20 °C, despite higher acute mortality at the higher temperature.• 2-Variation in family-based susceptibility to ISAv exposure ranged from 32 to 95% survival, and was linked to temperature.• 3-Viral prevalence disappeared quicker at 20 °C compared to 10 °C.• 4- Innate antiviral response was higher at 10 °C as demonstrated by genes such as mx1, isg15, and vprn, as well as the Th2 response, demonstrated by il10 and il4/13a.• 5- The Th1 and antigen presenting cells response was initially greater at 20 °C, as seen in il12rb2 and nkl, which may therefore play a role in viral clearance.