N. Sayed, Yingxiang Huang, Khiem Nguyen, Zuzana Krejciova-Rajaniemi, A. Grawe, Tianxiang Gao, R. Tibshirani, T. Hastie, A. Alpert, Lu Cui, T. Kuznetsova, Y. Rosenberg-Hasson, R. Ostan, D. Monti, B. Lehallier, S. Shen-Orr, H. Maecker, C. Dekker, T. Wyss‐Coray, C. Franceschi, V. Jojic, F. Haddad, J. G. Montoya, Joseph C. Wu, Mark M. Davis, David Furman
2021.7.1Nature Aging
tlooto Summary
An inflammatory clock of aging is developed that tracks with multimorbidity, immunosenescence, frailty and cardiovascular aging, and is also associated with exceptional longevity in centenarians, and the main contributor to iAge is the chemokine CXCL9, which is shown to control endothelial cell senescence and function.
Abstract
Abstract is not available.
Citation format
SAYED, N., et al. An inflammatory aging clock (iage) based on deep learning tracks multimorbidity, immunosenescence, frailty and cardiovascular aging. Nature Aging, 2021, 1: 598–615.