Network Physiology in Aging and Frailty: The Grand Challenge of Physiological Reserve in Older Adults

Discipline of Medical Gerontology, School of Medicine, Trinity College Dublin, Dublin, Ireland, Mercer’s Institute for Successful Ageing, St James’s Hospital, Dublin, Ireland, Global Brain Health Institute, Trinity College Dublin, Dublin, Ireland, Navarrabiomed, Complejo Hospitalario de Navarra (CHN), Public University of Navarra (UPNA), Navarra Health Research Institute (IdisNa), Pamplona, Spain, Faculty of Medicine, Imperial College London, Heart Science, National Heart and Lung Institute, London, United Kingdom, Geriatric Department, University of Florence and Azienda Ospedaliero Universitaria Careggi, Florence, Italy, Department of Clinical Sciences, Lund University and Department of Cardiology, Skåne University Hospital, Malmo, Sweden, Ageing Research Centre, School of Allied Health, Health Research Institute, University of Limerick, Limerick, Ireland, Physiotherapy and Geriatric Medicine, Dalhousie University, Halifax, NS, Canada, School of Medicine, Trinity College Dublin, University College Dublin and Our Lady’s Hospice and Care Services, Dublin, Ireland, Trinity Centre for Biomedical Engineering, Trinity College Dublin, Dublin, Ireland, Department of Geriatric Medicine, Radboud University Medical Center, Nijmegen, Netherlands, Discipline of Physiology, School of Medicine, Trinity College Dublin, Dublin, Ireland, Keck Laboratory for Network Physiology, Boston University, Boston, MA, United States