Dibutyltin(IV) complex of 2-[(E)-(4-hydroxy-3-{(E)-[(quinolin-2-yl)imino] methyl} phenyl) diazenyl]benzoic acid: Synthesis, spectroscopy and in vitro antifungal activity

ABSTRACT: Dibutyltin(IV) complex of 2-[(E)-(4-hydroxy-3-{(E)-[(quinolin-2-yl)imino] methyl} phenyl) diazenyl]benzoic acid was synthesized by refluxing 2-[(E)-(4-hydroxy-3-{(E)-[(quinolin-2- yl) imino] methyl} phenyl) diazenyl]benzoic acid with dibutyltin(IV) oxide in hot toluene. The complex was characterized by elemental analysis in combination with UV-visible, IR, 1H, 13C, 119Sn NMR spectroscopy and Mass spectrometry technique. The carboxylate ligand acts as chelating bidentate mode of coordination with the tin atom in the complex. The complex exhibited cyclic dimeric structure in the solution state where the tin centers adopt 6- coordinate octahedral geometry. The in vitro antifungal property of the ligand and the complex was observed and compared with reference drug, Amphotericin-B.