MedicineEnvironmental Science

J. E. Lima, N. C. Moreira, E. Sakamoto-Hojo

2022MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

DOI: 10.1016/j.mrgentox.2021.503437

tlooto Summary

This review focuses on the mechanisms by which oxidative stress, mitochondrial dysfunction, ER stress, and inflammation are involved in the pathophysiology of T2D, highlighting the importance of the antioxidant response and DNA repair mechanisms counteracting the development of the disease.

Abstract

Abstract is not available.

Citation format

LIMA, J. E.; MOREIRA, N. C.; SAKAMOTO-HOJO, E. Mechanisms underlying the pathophysiology of type 2 diabetes: From risk factors to oxidative stress, metabolic dysfunction, and hyperglycemia. MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS, 2022, 874-875: 503437.