Medicine

N. Bosma, M. Warkentin, C. Gan, S. Karim, D. Heng, D. Brenner, R. Lee-Ying

2022.1.22European Urology Open Science

DOI: 10.1016/j.euros.2021.12.007

tlooto Summary

Longer follow-up is required to determine if the benefits of IO-TKI regimens will be sustained and if they should be favored in the first-line treatment of mRCC.

Abstract

Take Home Message Immunotherapy-tyrosine kinase inhibitor (IO-TKI) drug combinations are associated with consistent improvements in clinically relevant outcomes for all risk groups in metastatic renal cell carcinoma (mRCC). Longer follow-up is required to determine if the benefits of IO-TKI regimens will be sustained and if they should be favored in the first-line treatment of mRCC.

Citation format

BOSMA, N., et al. Efficacy and safety of first-line systemic therapy for metastatic renal cell carcinoma: A systematic review and network meta-analysis. European Urology Open Science, 2022, 37: 14–26.