Vascular pathology and pathogenesis of cognitive impairment and dementia in older adults

Highlights • Cerebrovascular pathologies are common in the brains of older people and severity increase with advancing age.• Vascular pathologies associate with the development of VCI and contribute to the clinical picture judged to be Alzheimer's disease.• Vascular pathology often coexists along with other brain pathologies, most frequently with Alzheimer's disease, a phenomenon known as mixed pathologies.• Mixed vascular and AD pathologies have increased role in the pathogenesis of cognitive impairment and development of dementia.