H. Avagyan, A. Mirzoyan, F. Mirzoyan, Roza Izmailyan, Sona Hakobyan, H. Voskanyan, Z. Semerjyan, A. Avetisyan, H. Arzumanyan, E. Karalova, L. Abroyan, L. Hakobyan, N. Bayramyan, N. Gevorgyan, Alexander Karalyan, Z. Karalyan
tlooto Summary
In vitro and In vivo assays in several tissue cultures as well as in laboratory animals, conformed ‘Vomifal’ has a very low toxicity and the antiviral properties partially are due to its ability to induce gamma-IFN.
Abstract
The water-based combination of two inorganic chemical compounds such as sodium tungstate dihydrate-Na2WO4 × 2H2O and Aluminum sulfate octadecahydrate-Al2 (SO4) 3 × 18H2O that we have conditionally named ‘Vomifal’ has a broad antiviral activity in various DNA and RNA viruses, including Human Herpes Virus (HHV), African Swine Fever Virus (ASFV), Vaccinia Virus (VV), Hepatitis C Virus (HCV), Foot and Mouth Disease Virus (FMDV), Influenza A virus (A/Aichi/2/68 (H3N2)). In vitro and In vivo assays in several tissue cultures as well as in laboratory animals, conformed ‘Vomifal’ has a very low toxicity and the antiviral properties partially are due to its ability to induce gamma-IFN. Based on the results obtained, we can assume the presence of at least two mechanisms of the antiviral action of the studied drug. First or early stage - an unknown mechanism, possibly related to the effect on cellular receptors. Second or late stage – main antiviral properties probably associated with an interferonogenic effect.
Citation format
AVAGYAN, H., et al. New composition of tungsten has a broad range of antiviral activity. Antiviral Chemistry and Chemotherapy, 2022, 30.