Clinical diagnosis of Alzheimer's disease: Report of the NINCDS—ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease

Clinical criteria for the diagnosis of Alzheimer’s disease include insidious onset and progressive impairment of memory and other cognitive functions, and Alterations in transmitter-specific markers include forebrain cho-linergic systems and noradrenergic and somatostatinergic systems that innervate the telencephalon.