A. Tabatabai, J. Rabin, Jay Menaker, R. Madathil, Samuel M. Galvagno, A. Menne, J. Chow, Alison Grazioli, D. Herr, Kenichi A. Tanaka, T. Scalea, Michael A. Mazzeffi
2020.5.1A & A Practice
tlooto Summary
A case series of 10 critically ill patients with COVID-19 who had severe elevations in factor VIII activity and low normal functional protein C activity, which may have contributed to hypercoagulability are presented.
Abstract
Critically ill patients with coronavirus disease 2019 (COVID-19) have been observed to be hypercoagulable, but the mechanisms for this remain poorly described. Factor VIII is a procoagulant factor that increases during inflammation and is cleaved by activated protein C. To our knowledge, there is only 1 prior study of factor VIII and functional protein C activity in critically ill patients with COVID-19. Here, we present a case series of 10 critically ill patients with COVID-19 who had severe elevations in factor VIII activity and low normal functional protein C activity, which may have contributed to hypercoagulability.
Citation format
TABATABAI, A., et al. Factor VIII and functional protein c activity in critically ill patients with coronavirus disease 2019: A case series. A & A Practice, 2020, 14: e01236-e01236.