Open AccessChemistryMedicine

Fandi Sutanto, M. Konstantinidou, A. Dömling

2020.7.2RSC Medicinal Chemistry

DOI: 10.1039/d0md00154f

tlooto Summary

In this review, a brief historic overview of covalent inhibitors is provided and recent advances focusing on developments in the last decade are summarized.

Abstract

In this review we provide a brief historic overview of covalent inhibitors and summarize recent advances focusing on developments in the last decade. Applications in challenging targets and future perspectives are also discussed.

Citation format

SUTANTO, Fandi; KONSTANTINIDOU, M.; DÖMLING, A. Covalent inhibitors: A rational approach to drug discovery. RSC Medicinal Chemistry, 2020, 11: 876–884.