Immune imbalance mechanism and intervention strategy in patients with Coronavirus disease 2019 (COVID-19)
C. Yang, J. Qu, Y. T. Liu, S. Meng, B. Wang, M. Feng, Y. Sun
tlooto Summary
The similarities and differences of three coronaviruses are summarized in terms of gene, origin, infectiousness and pathogenicity, and new therapeutic strategies and ideas are put forward for the prevention and treatment of Coronavirus disease 2019.
Abstract
Coronaviruses, a large family of single-stranded RNA viruses, are responsible for three large-scale worldwide epidem¬ics in the first two decades of the 21st century Thus, it is im¬perative to strengthen the research on coronaviruses This review summarizes the similarities and differences of three coronaviruses (including SARS-CoV, MERS-CoV, SARS-CoV-2) in struc¬ture, gene, origin, infectiousness and pathogenicity Then, the review illuminates immune response mechanism and intervention strategies in terms of cytokine storm, neutrophil extracellular traps, imbalance of lymphocyte subsets in patients infected with coronaviruses based on experimental studies and clinical cases reports Finally, new therapeutic strategies and ideas are put forward for the prevention and treatment of Coronavirus disease 2019( COVID-19)
Citation format
YANG, C., et al. Immune imbalance mechanism and intervention strategy in patients with coronavirus disease 2019 (COVID-19). Chinese Pharmacological Bulletin, 2020, 36: 445–453.