Analysis of adenovirus infection in acute respiratory tract infection cases in Shanghai from 2015 to 2019

Objective To study the epidemiological characteristics and mixed infection of adenovirus in acute respiratory tract infections in Shanghai from 2015 to 2019, and to provide scientific basis for the prevention and control of adenovirus Methods Acute respiratory tract infections were collected from 3 hospitals in Shanghai from 2015 to 2019 Relevant information was registered and respiratory specimens were sampled for detection of respiratory pathogens by multiplex PCR Results A total of 1 543 cases of acute respiratory tract infection were included The positive rate of adenovirus was 2 92%(45/1 543), the positive rates of influenza like illness (ILl) and severe acute respiratory illness (SARI) were 2 74%(29/1 058) and 3 30%(16/485), respectively The positive rate of ILl during January-May 2019 was 5 43%(7/129), higher than that in the same period of 2015- 2018 (0 52%-4 48%) (Fisher' s exact test value8 92, P0 036) The incidence of adenoviruspositive cases was mainly distributed in the first and second quarters, accounting for 62 22% (28/45) The difference of the incidence of adenovirus-positive cases in each quarter was significant (x 41 5flJj Chin J Epidemiol,May 2020,Vol 41 ,No 5 12 52, P0 006) The positive rate in the second quarter was highest (6 03%), which was higher than that in other quarters (1 89%-2 93%) There were significant differences among different age groups (x216 94, P0 001), and the positive rate decreased with age (x210 16, P0 001) The positive rate of 13-19 years old group (9 43%) was higher than that of other age groups (1 48% - 4 81%) The positive rate of student group (12 07%) was higher than that of other occupations (2 61%) The difference was systematic (,2 - 11 53, P- 0 001) Mixed infection accounted for 31 11% (14/45) of 45 adenovirus positive cases The mixed infection rates of ILl and SARI were 34 48% (10/ 29) and 25 00% (4/16), respectively Among 14 cases of mixed infection, the main mixed infection pathogens of adenovirus were influenza A virus and coronavirus Conclusion Adenovirus surveillance should be further strengthened in adolescents with a focus on students and other key groups in the second quarter