The Impact of Different Modes of Exercise Training on Irisin: A Systematic Review and Meta-Analysis Research

Although the beneficial effects of exercise are well documented, the molecular mechanisms by which exercise prevents chronic diseases and improves health are poorly understood. Skeletal muscles have been identified as an active endocrine organ. They have critical functions in metabolic homeostasis by releasing hormones, called myokine, during muscle contraction (1). Myokines mediate crosstalk between tissues, such as the adipose tissue, liver, skin, and pancreas. They locally affect muscles and impose metabolic impacts through autocrine, paracrine, and endocrine signaling (1).