Open AccessMedicineBiology

ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome.

Christophe Ginestier, M. Hur, E. Charafe-Jauffret, F. Monville, J. Dutcher, Marty Brown, J. Jacquemier, P. Viens, C. Kleer, Suling Liu, A. Schott, D. Hayes, D. Birnbaum, M. Wicha, G. Dontu

2007.11.15Cell Stem Cell

DOI: 10.1016/j.stem.2007.08.014

tlooto Summary

It is shown that normal and cancer human mammary epithelial cells with increased aldehyde dehydrogenase activity (ALDH) have stem/progenitor properties and these cells contain the subpopulation of normal breast epithelium with the broadest lineage differentiation potential and greatest growth capacity in a xenotransplant model.

Abstract

Abstract is not available.

Citation format

GINESTIER, Christophe, et al. ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome. Cell Stem Cell, 2007, 1 5: 555–67.