ChemistryMedicine

Drug-like properties and the causes of poor solubility and poor permeability.

C. Lipinski

2000.7.1JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

DOI: 10.1016/s1056-8719(00)00107-6

tlooto Summary

There are currently about 10000 drug-like compounds, and true diversity does not exist in experimental combinatorial chemistry screening libraries because current ADME experimental screens are multi-mechanisms, and predictions get worse as more data accumulates.

Abstract

Abstract is not available.

Citation format

LIPINSKI, C. Drug-like properties and the causes of poor solubility and poor permeability. JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS, 2000, 44 1: 235–49.