Carol Ward, J. Meehan, M. Gray, Alan F. Murray, D. Argyle, Ian H Kunkler, Simon P. Langdon
tlooto Summary
Progress in the development of inhibitors to targets associated with the control of intracellular pH, including carbonic anhydrase IX, the monocarboxylate transporters, the vacuolar-type H+-ATPase proton pump, and the sodium-hydrogen exchanger 1 are described.
Abstract
Dysregulation of cellular pH is frequent in solid tumours and provides potential opportunities for therapeutic intervention. The acidic microenvironment within a tumour can promote migration, invasion and metastasis of cancer cells through a variety of mechanisms. Pathways associated with the control of intracellular pH that are under consideration for intervention include carbonic anhydrase IX, the monocarboxylate transporters (MCT, MCT1 and MCT4), the vacuolar-type H+-ATPase proton pump, and the sodium-hydrogen exchanger 1. This review will describe progress in the development of inhibitors to these targets.
Citation format
WARD, Carol, et al. The impact of tumour ph on cancer progression: Strategies for clinical intervention. Exploration of Targeted Anti-tumor Therapy, 2020, 1: 71–100.