Neuroleptic Malignant Syndrome

Background: Neuroleptic malignant syndrome (NMS) is a rare but potentially fatal, an idiosyncratic reaction to neuroleptics/anti psychotics characterised by rigidity, fever, autonomic dysfunction and altered consciousness with elevated levels of creatinine phosphokinase (CPK) and leucocytosis. It occurs in 0.4% of newly treated patients and carries mortality risk of 22%. Abstract: with the above background, we report a case of 48 yr old female with diagnosis of paranoid schizophrenia started on parenteral haloperidol, oral quetiapine and risperidone, amisulpride developed fever, rigidity and altered sensorium after 2 days of initiation of above drugs which was later diagnosed as neuroleptic malignant syndrome. Early recognition of syndrome, immediate discontinuation of the offending agent and treatment with lorazepam and other supportive measures resulted in prompt recovery of patient without any complications.