Vitamin D and platelet Rich Plasma (PRP) in the treatment of vitiligo

Vitamin D and Platelet Rich Plasma (PRP) in the treatment of Vitiligo Background: Vitiligo is an autoimmune disorder which is caused by the destruction of melanocytes in the skin. Vitamin D is a fat-soluble vitamin that controls cell proliferation and differentiation and exerts immunoregulatory activities. PlateletRich Plasma (PRP) may serve as a source of different growth factors to induce pigmentation in vitiligo. Aim of the work: to explore the effect of intralesional platelet rich plasma and vitamin D injection in vitilgo patients. Patients and methods: The study included two groups of stable non segmental vitiligo patients. Each group included 20 patients. Group A: Each patient was injected PRP intralesionaliy in vitiligenous patch and PRP together with vitamin D intralesionally in another vitiligenous patch. Group B : Each patient was injected vit D intralesionally in vitiligenous patch and PRP together with vitamin D intralesionally in another vitiligenous patch . Results: Group A revealed highly statistically significant difference between baseline and after 3 months follow up regarding improvement of pigmentation in both PRP +vit. D patch (p < 0.001) and in PRP group (p < 0.001). Group B revealed highly statistically significant difference between baseline and after 3 months follow up regarding degree of improvement of pigmentation in PRP + vit D group (p < 0.001). It revealed statistically significant difference between baseline and after 3 months follow up regarding degree of improvement of pigmentation in vit D group (p < 0.05). Conclusion: In conclusion, PRP injection either alone or with vit. D has good satisfactory results in treatment of vitilig. Vit.D injection alone showed less satisfactory results than combined treatment regarding degree of improvement.