Catalytic Alkyne ReactionsCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling Reactions
β-and Z-Selective Metal-Free Cyanation of Ynamides: A Direct Approach to Piperidines Fused to Arenes
Dorian Schutz, Wenwen Yang, L. Miesch
2026.1.1Organic Chemistry Frontiers
Abstract
Metal-free βand Z-selective hydrocyanation of terminal ynamides using TMSCN and TBAF is described. The transformation proceeds with excellent regio-and stereoselectivity, delivering exclusively Z-configured tertiary enamides. Treatment with TMSOTf promotes clean...
Citation format
SCHUTZ, Dorian; YANG, Wenwen; MIESCH, L. β-And z-selective metal-free cyanation of ynamides: A direct approach to piperidines fused to arenes. Organic Chemistry Frontiers, 2026, 13(8): 2459–2465.