Formulation development and evaluation o... - tlooto, The Most Powerful AcademicGPT

The development and evaluation of a vonoprazan-loaded nanosuspension represent a promising formulation strategy to overcome the solubility and bioavailability limitations of this potassium-competitive acid blocker (P-CAB). Vonoprazan exhibits superior and rapid acid suppression efficacy compared to conventional proton pump inhibitors (PPIs), which has been demonstrated clinically in erosive esophagitis and acid-related disorders [1][2][3]. However, its poor aqueous solubility (0.045 mg/mL) constrains oral bioavailability, which nanosuspensions can effectively address. Formulation Development Nanosuspensions are submicron colloidal dispersions of drug particles stabilized by surfactants or polymers. They leverage particle size reduction to nanoscale dimensions ([4][5]. Optimization through Design of Experiment (DoE) methods like Box–Behnken design enables fine-tuning critical variables such as drug-to-stabilizer ratio, sonication time, and homogenization speed to achieve desirable parti